Lichun He

A Regulatory Role of Molecular Chaperones in Excited States and Functions of Folded Enzymes

This study shows chaperones modulate enzyme activity in native states, expanding their role beyond protein folding.

NMR-guided rational exploration of co-factors in boosting the Pfu DNA polymerase

The paper identifies two co-factors that enhance Pfu DNA polymerase performance using NMR-based hot spot residue screening without prior structural data.

Functional Hotspots Identification via a Hybrid NMR-Computational Approach Facilitating Directed Evolution of Large Enzyme

This paper identifies functional hotspots in large enzymes using a hybrid NMR-computational approach, enabling efficient directed evolution with targeted mutagenesis.

Oligopeptide (FK)4 facilitates the determination of the absolute stereochemistry of chiral organic compounds via NMR Spectroscopy

This study demonstrates how the oligopeptide (FK)4 enables the determination of absolute stereochemistry of chiral compounds using NMR spectroscopy by combining alignment medium and chiral differentiating properties.