Author

Karel Chalupský

Czech Academy of SciencesORCID 0000-0001-6890-6464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1

Frequent Co-Authors

Dominika ChalupskáiD· 2 shared Evžen BouřaiD· 2 shared Martin KlímaiD· 2 shared Andrea EisenreichováiD· 1 shared Barbora NovotnáiD· 1 shared Eva KonkoľováiD· 1 shared Gabriel BirkušiD· 1 shared Kateřina KrejčováiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Dominika ChalupskáORCID

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2 papers

Recent·Most cited

Molecular BiologyStructurePeer-reviewedMay 22, 2024

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

Kateřina Krejčová, Petra Krafčíková, Martin Klíma…·Evžen Bouřa

The paper structures and biochemically analyzes the MTase and RdRp domains of Ntaya virus NS5, showing conserved enzymatic centers across Flaviviridae but differing MTase activities.

16 citationstop 3%

protein structureexperimental assay

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Molecular BiologyStructurePeer-reviewedFeb 6, 2024

Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: structural basis of their function

Martin Klíma, Milan Dejmek, Vojtěch Duchoslav…·Evžen Bouřa

This study designs and synthesizes fluorinated cGAMP analogs that are stable against poxin cleavage and show high STING activation, with structural insights into their binding modes.

19 citations

experimental assay

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