Author

Petra Krafčíková

Czech Academy of SciencesORCID 0000-0002-3363-2499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 2 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Evžen BouřaiD· 3 shared Dominika ChalupskáiD· 1 shared Eva KonkoľováiD· 1 shared Hana CahováiD· 1 shared Jan ŠilhániD· 1 shared Joanna KowalskaiD· 1 shared Karel ChalupskýiD· 1 shared Kateřina KrejčováiD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersMolecular Biology

Evžen BouřaORCID

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3 papers

Recent·Most cited

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

Kateřina Krejčová, Petra Krafčíková, Martin Klíma, Dominika Chalupská, Karel Chalupský, Eva Konkoľová, Evžen Bouřa

The paper structures and biochemically analyzes the MTase and RdRp domains of Ntaya virus NS5, showing conserved enzymatic centers across Flaviviridae but differing MTase activities.

Structure · May 22, 2024Peer-reviewedMolecular Biology

Substrate specificity of SARS-CoV-2 nsp10-nsp16 methyltransferase

Marek R. Baranowski, Petra Krafčíková, Hana Cahová, Evžen Bouřa, Joanna Kowalska, Roberto Benoni

The paper identifies five capped RNA substrates for SARS-CoV-2 nsp10-nsp16 methyltransferase using an LC-MS-based method and determines the IC50 of sinefungin.

bioRxiv · Jul 30, 2020Molecular Biology

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in coronaviral RNA cap creation

Petra Krafčíková, Jan Šilhán, Radim Nencka, Evžen Bouřa

The paper solves the crystal structure of the SARS-CoV-2 nsp10-nsp16 MTase complex and models its interaction with RNA, revealing low conservation with Zika MTase and implications for inhibitor design.

Nature Communications · Jul 24, 2020Peer-reviewedMolecular Biology