Dominika Chalupská

Characterization of the N7 RNA cap methyltransferase from Trichomonas vaginalis and inhibitor discovery

The paper functionally and structurally characterizes RNA cap methyltransferases from Trichomonas vaginalis and identifies inhibitors targeting these enzymes.

Branched C7-Substituted 7-Deaza-SAH Analogues Occupy the Entire SAM-Binding Pocket of Mpox Virus VP39 and Dengue Virus NS5 Methyltransferases

The paper develops branched C7-substituted 7-deaza-SAH analogues that inhibit mpox virus VP39 and dengue virus NS5 methyltransferases by occupying their SAM-binding pockets.

Structural and functional insights in flavivirus NS5 proteins gained by the structure of Ntaya virus polymerase and methyltransferase

The paper structures and biochemically analyzes the MTase and RdRp domains of Ntaya virus NS5, showing conserved enzymatic centers across Flaviviridae but differing MTase activities.

Fluorinated cGAMP analogs, which act as STING agonists and are not cleavable by poxins: structural basis of their function

This study designs and synthesizes fluorinated cGAMP analogs that are stable against poxin cleavage and show high STING activation, with structural insights into their binding modes.