Nardhy Gomez‐Lopez

A single-cell transcriptomic atlas of the periventricular proliferative zone in the late gestation fetal brain in the pigtail macaque

The paper constructs a single-cell RNA-Seq atlas of the periventricular proliferative zone in late-gestation pigtail macaque fetal brain, revealing cell states similar to human fetal brain.

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologies

This paper creates an integrated multimodal atlas of the female reproductive system across the lifespan, identifying cell types and linking them to gynaecological pathologies.

Single-cell transcriptomics of heterogeneous patient-derived organoids reveals novel therapeutic targets in high-grade serous ovarian cancer

This study uses single-cell transcriptomics on patient-derived organoids to identify AGRIN as a regulator of metastatic competence in high-grade serous ovarian cancer.

Upregulation of MAM by C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer disease.

This study identifies how C99 disrupts ACSL4 activity and phospholipid homeostasis in Alzheimer's disease by remodeling MAMs and altering PC composition.

Cultivation and molecular characterization of Foley catheterized urine, clean catch urine, and vaginal swabs from pregnant women prior to delivery

The paper characterizes the urinary microbiota of pregnant women using catheter urine, clean catch urine, and vaginal swabs, finding that Foley catheter urine better captures low-abundance bladder microbes.

The contribution of mitochondria-associated ER membranes to cholesterol homeostasis

This study shows that SR-B1-mediated cholesterol uptake from HDL stimulates MAM formation, which suppresses de novo cholesterol biosynthesis.

Lipopolysaccharide induces placental mitochondrial dysfunction by reducing MNRR1 levels via a TLR4-independent pathway

This study shows that lipopolysaccharide reduces MNRR1 levels in placental tissues, leading to mitochondrial dysfunction and inflammation via a TLR4-independent pathway.

Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth

The paper develops predictive models for preterm birth using maternal blood multi-omics data, finding transcriptomic and proteomic markers can predict gestational age and spontaneous preterm birth with high accuracy.

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

The paper investigates ACE2 and TMPRSS2 expression in human placenta across pregnancy stages and finds negligible co-expression, suggesting SARS-CoV-2 is unlikely to infect placenta via canonical entry mediators.

Separating the signal from the noise in metagenomic cell-free DNA sequencing

The paper introduces LBBC, a tool to reduce noise in metagenomic cfDNA sequencing, improving detection of urinary tract infection while minimizing false positives.

Single Cell Transcriptional Signatures of the Human Placenta in Term and Preterm Parturition

The paper uses scRNA-seq to analyze placental tissues from term and preterm births, identifying cell type differences and transcriptional signatures associated with labor.