Gut Microbiome-Produced Bile Acid Metabolite Lengthens Circadian Period in Host Intestinal Cells
Chelsea E. Powell, Alana M. McSween, Lenka Dohnalová, Cecilia H. Kim, Robyn J. Eisert, Zhen-Yu J. Sun, Hyuk‐Soo Seo, Vincent Marquardt, Sirano Dhe‐Paganon, Christoph A. Thaiss, A. Sloan Devlin
The paper identifies lithocholic acid as a bile acid metabolite that modulates circadian rhythms in intestinal cells by affecting core clock proteins and feedback loops.
Proceedings of the National Academy of Sciences · Mar 11, 2026Peer-reviewedCell Biology