P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis
Jing Ma, Sally Kit Yan To, Katie Sze Wai Fung, Kun Wang, Jiangwen Zhang, Alfonso H.W. Ngan, Susan Yung, Tak Mao Chan, Carmen Chak‐Lui Wong, Philip P.C. Ip, Ling Peng, Hongyan Guo, Chi Bun Chan, Alice S.T. Wong
This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.
Cell Reports · Dec 18, 2024Peer-reviewedCancer Biology