Utz Herbig

The paper identifies a senescence-like transitional state in aging human monocytes driven by AP-1, leading to inflammatory monocyte expansion and systemic inflammation.

This study identifies epigenetic regulators of CD8+ T cell senescence in aging humans using multiomic profiling and shows their relevance to disease progression.

This study identifies senescent CD8+ T effector memory cells as functionally impaired and enriched in aging and disease, and shows they hinder immunotherapy responses.

The paper identifies POU2F2 and chromatin scars as mechanisms enabling escape from oncogene-induced senescence and their potential as biomarkers in colorectal cancer.

The paper identifies AP-1's role in shaping the epigenetic landscape of senescent cells and presents a hierarchical TF network model for senescence reprogramming.