Ricardo Iván Martínez‐Zamudio

Chromatin states coordinate diurnal gene expression in the Drosophila retina

The paper shows that chromatin states, not just circadian transcription factors, coordinate diurnal gene expression in Drosophila photoreceptor neurons by aligning gene phases with promoter, enhancer, or repressive chromatin signatures.

A transitional senescence program drives inflammatory monocyte state expansion in aging humans

The paper identifies a senescence-like transitional state in aging human monocytes driven by AP-1, leading to inflammatory monocyte expansion and systemic inflammation.

Epigenetic mechanisms regulating CD8+ T cell senescence in aging humans

This study identifies epigenetic regulators of CD8+ T cell senescence in aging humans using multiomic profiling and shows their relevance to disease progression.

Senescent CD8+ T Effector Memory Cells are Functionally Impaired, Enriched in Aging and Disease, and a Barrier to Immunotherapy

This study identifies senescent CD8+ T effector memory cells as functionally impaired and enriched in aging and disease, and shows they hinder immunotherapy responses.

Escape From Oncogene-Induced Senescence is Controlled by POU2F2 and Memorized by Chromatin Scars

The paper identifies POU2F2 and chromatin scars as mechanisms enabling escape from oncogene-induced senescence and their potential as biomarkers in colorectal cancer.

AP-1 Imprints a Reversible Transcriptional Program of Senescent Cells

The paper identifies AP-1's role in shaping the epigenetic landscape of senescent cells and presents a hierarchical TF network model for senescence reprogramming.