Dissecting quantitative trait nucleotides by saturation genome editing
Kevin R. Roy, Justin Smith, Shengdi Li, Sibylle Chantal Vonesch, Michelle Nguyen, Wallace T. Burnett, Kevin M. Orsley, Cheng‐Sheng Lee, James E. Haber, Robert P. St.Onge, Lars Michael Steinmetz
The paper develops MAGESTIC 3.0, a CRISPR-based system for genome-wide variant installation in yeast, revealing missense variants and multiple causal variants in quantitative trait loci across environmental conditions.
bioRxiv · Feb 2, 2024 · PreprintGenetics