Michelle Nguyen

SH2scan: Mapping SH2 domain-ligand binding selectivity for inhibitors and degraders

SH2scan quantifies ligand-SH2 domain interactions across >80% of targets, revealing binding selectivity and KDs to aid in designing selective inhibitors and degraders.

Zika virus induces persistent phenotypic changes in natural killer cells distinct from dengue virus infection

This study compares NK cell receptor expression in ZIKV and dengue-infected individuals, finding persistent phenotypic changes in ZIKV infection and virus-specific differences in NK cell activation.

Dissecting quantitative trait nucleotides by saturation genome editing

The paper develops MAGESTIC 3.0, a CRISPR-based system for genome-wide variant installation in yeast, revealing missense variants and multiple causal variants in quantitative trait loci across environmental conditions.

Transcript fusion between CDKN1A and RAB44 caused by exon skipping like mechanism due to disruption of a splice site

The paper identifies a recurrent tumor-specific transcript fusion between CDKN1A and RAB44 caused by splice-site mutations and shows its correlation with TP53 inactivation and CDK activation.