Sinan Shi

This paper builds a haplotype reference panel from Genomics England data and imputes UK Biobank data, revealing more rare variants and suggesting limitations in detecting rare variant associations with current sample sizes.

The paper shows genetic effect sizes are similar across African and European populations for most traits, suggesting shared causal mutations and improving GWAS portability.

This paper introduces a method to estimate genome-wide genealogies for thousands of samples, revealing new insights into human evolutionary history and selection.

This study performs genome-wide association analyses on brain imaging phenotypes from UK Biobank, identifying 148 significant SNP-imaging associations with potential relevance to neurological and psychiatric disorders.