Kevin Sharp

UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits

The paper releases and evaluates polygenic risk scores for 53 diseases and traits in the UK Biobank and shows they outperform existing scores.

Enhanced Brain Imaging Genetics in UK Biobank

The paper expands genetic associations with brain imaging phenotypes using updated UK Biobank data, finding more genetic variants and associations, including on the X chromosome.

Genome-wide association studies of brain structure and function in the UK Biobank

This study performs genome-wide association analyses on brain imaging phenotypes from UK Biobank, identifying 148 significant SNP-imaging associations with potential relevance to neurological and psychiatric disorders.

Narrow-sense heritability estimation of complex traits using identity-by-descent information.

This paper estimates narrow-sense heritability using identity-by-descent information in unrelated individuals and finds that IBD-based methods can capture rare variant contributions but are affected by stratification.

Genome-wide genetic data on ~500,000 UK Biobank participants

Quality-controlled genotypes for 488,377 UK Biobank participants at 805,426 markers, imputed to ~96 million variants, plus ancestry PCs, kinship (30.3% have close relatives enrolled) and HLA calls.

Explaining Missing Heritability Using Gaussian Process Regression

This paper uses Gaussian Process Regression to explain missing heritability in yeast and rat phenotypes, finding that non-additive interactions account for most of the missing heritability.