María Calvo-Rodríguez

The paper introduces a shallow-angle cannula for repeated drug delivery and in vivo imaging in mice, demonstrating its use for tracking degenerating neurons and measuring brain oxygen levels.

The paper uses real-time imaging to show increased mitochondrial oxidative stress in neurons near Aβ plaques in a mouse model of Alzheimer's disease, and demonstrates that this stress can be reduced by targeting calcium influx or using antioxidants.