Brian J. Bacskai

This study shows anti-Aβ immunotherapy triggers rapid immune-vascular interactions in the leptomeningeal interface, leading to peripheral immune cell adhesion and potentially contributing to ARIA.

This paper introduces an ultra-high-resolution MRI framework to map perivascular spaces (PVS) across the whole brain, revealing their hierarchical organization along vascular trees.

This study shows amyloid plaques in the hippocampus cause long-range circuit reorganization in freely behaving mice, affecting place cell distribution and functional maps.

The paper introduces a shallow-angle cannula for repeated drug delivery and in vivo imaging in mice, demonstrating its use for tracking degenerating neurons and measuring brain oxygen levels.

This study records γ-secretase activity in living mouse brains using a NIR biosensor and microscopy, revealing cell non-autonomous regulation of the enzyme.

The paper investigates synaptic instability in experimental autoimmune encephalomyelitis, finding that excitatory synapses become unstable and reorganize before symptom onset, altering circuit inputs to cortical neurons.

The paper investigates firing rate changes in inhibitory interneurons near amyloid plaques in an Alzheimer's mouse model, finding hyperactivity in somatostatin-expressing interneurons and hypoactivity in parvalbumin-expressing interneurons.

The paper uses real-time imaging to show increased mitochondrial oxidative stress in neurons near Aβ plaques in a mouse model of Alzheimer's disease, and demonstrates that this stress can be reduced by targeting calcium influx or using antioxidants.