Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid beta aggregates in vivo in a mouse model of Alzheimer's disease
María Calvo-Rodríguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano‐Pozo, Brian J. Bacskai
The paper uses real-time imaging to show increased mitochondrial oxidative stress in neurons near Aβ plaques in a mouse model of Alzheimer's disease, and demonstrates that this stress can be reduced by targeting calcium influx or using antioxidants.
bioRxiv · Jun 12, 2022 · PreprintNeuroscience