Mathias Ziegler

GEMCAT predicts metabolic changes from transcriptomics or proteomics data and validates them with metabolomics, demonstrating its utility in human cell lines and inflammatory bowel disease patients.

The paper investigates how POLG genotype affects mitochondrial dysfunction in iPSC-derived neural progenitors, finding greater impairment in compound heterozygous lines compared to homozygous ones.

The paper introduces PICor, a tool for isotopologue correction in proteomics and metabolomics, demonstrating its importance for accurate analysis of protein modification dynamics.

This study shows that POLG mutations in astrocytes cause mitochondrial dysfunction and neurotoxicity, leading to neuronal death through altered metabolism and reactive astrocyte behavior.