Author

Cecilie Katrin Kristiansen

Haukeland University HospitalORCID 0000-0002-4217-424XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Anbin CheniD· 3 shared Kristina Xiao LiangiD· 3 shared Gareth J. SullivaniD· 2 shared Laurence Albert BindoffiD· 2 shared Lena Elise HøylandiD· 2 shared Mathias ZiegleriD· 2 shared Atefeh Kianian· 1 shared Charalampos TzoulisiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersNeuroscience

Anbin ChenORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 8, 2025

Metformin boosts mitochondria and neurogenesis via AMPK/mTOR/SIRT3 in POLG mutant organoids

Anbin Chen, Sebastian Edgar Schmidke, Cecilie Katrin Kristiansen, Kristina Xiao Liang

This study shows that metformin improves mitochondrial function and neurogenesis in POLG mutant brain organoids by activating the AMPK/SIRT3/mTOR pathway.

DOI 10.1101/2025.06.08.658480

humanscRNA-seq

𝕏 PostBluesky

NeuroscienceExperimental NeurologyPeer-reviewedApr 25, 2023

POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia

Hong Yu, Cecilie Katrin Kristiansen, Anbin Chen…·Kristina Xiao Liang

The paper investigates how POLG genotype affects mitochondrial dysfunction in iPSC-derived neural progenitors, finding greater impairment in compound heterozygous lines compared to homozygous ones.

6 citations

humanbulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 20, 2020

Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons

Kristina Xiao Liang, Atefeh Kianian, Anbin Chen…·Laurence Albert Bindoff

This study shows that POLG mutations in astrocytes cause mitochondrial dysfunction and neurotoxicity, leading to neuronal death through altered metabolism and reactive astrocyte behavior.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky