Author

Lena Elise Høyland

University of BergenORCID 0000-0002-7189-780XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anbin CheniD· 2 shared Cecilie Katrin KristianseniD· 2 shared Gareth J. SullivaniD· 2 shared Kristina Xiao LiangiD· 2 shared Laurence Albert BindoffiD· 2 shared Mathias ZiegleriD· 2 shared Atefeh Kianian· 1 shared Charalampos TzoulisiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Anbin ChenORCID

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Author profile →

2 papers

Recent·Most cited

POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia

Hong Yu, Cecilie Katrin Kristiansen, Anbin Chen, Gonzalo S. Nido, Lena Elise Høyland, Mathias Ziegler, Gareth J. Sullivan, Laurence Albert Bindoff, Kristina Xiao Liang

The paper investigates how POLG genotype affects mitochondrial dysfunction in iPSC-derived neural progenitors, finding greater impairment in compound heterozygous lines compared to homozygous ones.

Experimental Neurology · Apr 25, 2023Peer-reviewedNeuroscience

Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons

Kristina Xiao Liang, Atefeh Kianian, Anbin Chen, Cecilie Katrin Kristiansen, Yu Hong, Jessica Furriol, Lena Elise Høyland, Mathias Ziegler, Torbjørn Kråkenes, Charalampos Tzoulis, Gareth J. Sullivan, Laurence Albert Bindoff

This study shows that POLG mutations in astrocytes cause mitochondrial dysfunction and neurotoxicity, leading to neuronal death through altered metabolism and reactive astrocyte behavior.

bioRxiv · Dec 20, 2020 · PreprintNeuroscience