Anbin Chen

Metformin boosts mitochondria and neurogenesis via AMPK/mTOR/SIRT3 in POLG mutant organoids

This study shows that metformin improves mitochondrial function and neurogenesis in POLG mutant brain organoids by activating the AMPK/SIRT3/mTOR pathway.

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC derived Cortical Organoid of Alpers' Disease

This study uses iPSC-derived cortical organoids to model Alpers' disease and shows that nicotinamide riboside improves mitochondrial defects and neuronal loss.

Nicotinamide Riboside Supplementation Ameliorates Mitochondrial Dysfunction and Neuronal Loss in POLG Mutant Midbrain Organoids

This study shows that Nicotinamide Riboside improves mitochondrial function and neuron count in POLG mutant midbrain organoids.

Mitochondrial Dysfunction and Neuronal Anomalies in POLG Mutant Midbrain Organoids

This study develops a method to generate midbrain organoids from stem cells and shows that POLG mutant organoids exhibit neuronal loss and mitochondrial dysfunction, relevant to Parkinson's disease.

POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia

The paper investigates how POLG genotype affects mitochondrial dysfunction in iPSC-derived neural progenitors, finding greater impairment in compound heterozygous lines compared to homozygous ones.

Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons

This study shows that POLG mutations in astrocytes cause mitochondrial dysfunction and neurotoxicity, leading to neuronal death through altered metabolism and reactive astrocyte behavior.