Author

Juan L. Mendoza

Howard Hughes Medical InstituteORCID 0000-0001-6972-7476Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1 Immunology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Abdul Rouf BandayiD· 1 shared Adeola A Obajemu· 1 shared Aditya KrishnakumariD· 1 shared Aleksandra K. Kurowska· 1 shared Andrew FavoriD· 1 shared Angel Francisco LopeziD· 1 shared Carmon KeeiD· 1 shared Crystal O Leary· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperGenetics

Abdul Rouf BandayORCID

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 27, 2026

Graded and cross-reactive JAK-receptor interactions broaden the one-receptor, one-JAK rule

Mukesh Kumar Venkat Ramani, Juan L. Mendoza, Kailin Guo…·Haley A. Hardtke

The paper tests the one-receptor, one-JAK model by measuring JAK1 and TYK2 interactions with receptor ICDs, finding graded and cross-reactive binding rather than exclusive, constitutive interactions.

DOI 10.64898/2026.10.24.761551

experimental assay

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ImmunologybioRxivPreprintOct 19, 2026

High-Throughput Screening Identifies Proteasome Inhibitors as Potentiators of Type III Interferon JAK-STAT Signaling and Antiviral Immunity

Jean-Patrick Parisien, Crystal O Leary, Shima Shabani…·Juan L. Mendoza

DOI 10.64898/2026.10.12.758093

humanproteomics

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Synthetic BiologybioRxivPreprintOct 12, 2025

Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling

Marc Expòsit, Mohamad H. Abedi, Aditya Krishnakumar…·David A. Baker

This paper designs synthetic cytokine agonists with controlled receptor geometry to modulate signaling outcomes and functional effects.

3 citations

protein structureexperimental assay

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GeneticsNature GeneticsPeer-reviewedOct 19, 2020

Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2

Olusegun O. Onabajo, Abdul Rouf Banday, Megan Lynn Stanifer…·Ludmila Prokunina‐Olsson

The paper identifies a novel primate-specific ACE2 isoform, dACE2, which is an interferon-stimulated gene but not functional for SARS-CoV-2 entry.

261 citationstop 2%

humanstatistical model

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