Author

Mukesh Kumar Venkat Ramani

Howard Hughes Medical InstituteORCID 0000-0002-8950-8374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Haley A. HardtkeiD· 2 shared Alan GerberiD· 1 shared Edwin E. EscobariD· 1 shared Jennifer S. BrodbeltiD· 1 shared Jillian Bonilla· 1 shared Juan L. MendozaiD· 1 shared Kailin Guo· 1 shared Qian Zhang· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Haley A. HardtkeORCID

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2 papers

Recent·Most cited

Graded and cross-reactive JAK-receptor interactions broaden the one-receptor, one-JAK rule

Mukesh Kumar Venkat Ramani, Juan L. Mendoza, Kailin Guo, Yannik Leuz, Jillian Bonilla, Haley A. Hardtke

The paper tests the one-receptor, one-JAK model by measuring JAK1 and TYK2 interactions with receptor ICDs, finding graded and cross-reactive binding rather than exclusive, constitutive interactions.

bioRxiv · Oct 27, 2026 · PreprintBiochemistry

'Zipper' Grammar of CTD Governs the Spatial Programing of the Transcription Cycle of RNA Polymerase II

Qian Zhang, Haley A. Hardtke, Yuanmin Zheng, Alan Gerber, Mukesh Kumar Venkat Ramani, Edwin E. Escobar, Jennifer S. Brodbelt, Ruobo Zhou, Yan Zhang

The paper defines the minimal sequence requirements of RNA polymerase II CTD across transcriptional stages using structural analysis and synthetic constructs, revealing a 'zipper' model for PIC assembly and transcription progression.

bioRxiv · Jan 2, 2026 · PreprintCell Biology