Jay B. Bikoff

Corticospinal neuron subpopulations with opposing dynamics converge to shape spinal interneuron computations

The paper identifies corticospinal neuron subpopulations with opposing activity dynamics and shows they converge to shape spinal interneuron computations during skilled movement.

Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in mice

This study identifies striatal hypercholinergic state and thalamostriatal disruption as causes of amotivation in a 22q11DS mouse model.

Segregated basal ganglia output pathways correspond to genetically divergent neuronal subclasses

The paper identifies transcriptomically distinct subclasses in the substantia nigra pars reticulata (SNr) and shows their topographic organization, target projections, and conservation across species.

Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons and heterogeneity

The paper identifies four V1 interneuron clades in the spinal cord based on birthdate, lineage, and connectivity, showing functional differences in their synaptic connections and circuit roles.

Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis

The paper shows that spinal neuron diversity increases exponentially during frog metamorphosis as motor behavior shifts from swimming to limb use, with molecular similarities to mammalian circuits.

The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output

The paper presents a single-nucleus transcriptomic atlas of spinal V1 interneurons across development, identifying En1's role in specifying a subset of V1Pou6f2 interneurons and its impact on locomotor output.

Synaptic plasticity in human thalamocortical assembloids

This paper demonstrates that thalamocortical assembloids formed from human organoids exhibit functional glutamatergic synapses with short-term plasticity and distinct long-term potentiation and depression mechanisms compared to rodents.

A Novel Single Vector Intersectional AAV Strategy for Interrogating Cellular Diversity and Brain Function

The paper introduces ConVERGD, a single-construct intersectional AAV strategy for targeting specific cell populations, and demonstrates its use in targeting NE+ LC neurons expressing Pdyn in rodents.