Chang N. Kim

The paper isolates and characterizes two postnatal human neural stem cell subsets, showing their fate biases and decline in frequency over time.

The paper uses optogenetic WNT activation in human gastruloids to study germ layer self-organization and finds it drives mesendoderm differentiation and patterning.

The paper identifies transcription factors and effector genes involved in human cortical neurogenesis using CRISPRi screening in a primary culture system.

This paper introduces vascularized cortical assembloids (vCAs) that model neurovascular co-development and show improved cellular specialization and connectivity compared to standard cortical organoids.

ANTIPODE integrates single-cell data across species to identify homologous cell types and reveal gene regulatory divergence in developing mammalian brains.

This study shows that TS21 accelerates radial glia lineage progression, leading to premature production of inhibitory neurons and oligodendrocytes in Down syndrome.

The paper uses single cell and spatial transcriptomics to study thalamic development in humans, identifying molecular mechanisms of nuclei formation and neuron subtypes.

This study investigates rubella virus tropism in human brain slices and organoids, showing microglia as the primary target and revealing an interferon response in non-microglial cells.

DynaMorph uses self-supervised learning to analyze morphodynamic states of live human microglia, identifying distinct states and transitions in response to disease-relevant stimuli.

The paper characterizes bumblebee genomes across 17 species to identify genetic variation linked to ecological and behavioral traits, revealing insights into genome structure, evolution, and adaptation.

This study maps human microglia development and identifies cytokine-associated subtypes and functional roles in neural network maturation.

The paper maps chromatin accessibility in developing human brain and organoids using scATAC-seq, revealing cell type-specific regulatory elements and their role in neurodevelopment.