Alexandra Louis

The paper studies gene regulatory evolution in salmonids after autotetraploidization, finding that it is influenced by developmental and tissue-specific factors, with constraints at advanced embryogenesis.

The paper constructs a high-resolution comparative atlas of paleopolyploid regions across 74 teleost genomes to study rediploidization and finds that some duplicated regions remained tetraploid for over 60 million years.

This paper introduces FINSURF, a machine learning tool that improves the prediction of pathogenic non-coding variants, achieving high accuracy in identifying disease-causing variants in clinical settings.

SCORPiOs improves gene phylogenies in teleost fish by integrating syntenic information, resolving inconsistencies in 70% of gene families and enhancing congruence with species trees and expression patterns.

The paper reconstructs the chromosome evolution of the ancestral vertebrate genome through two whole genome duplications and subsequent fusions, resolving ambiguities in the lamprey genetic map and providing insights into micro-chromosome origins.