Cancer BiologybioRxivPreprint
Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer
Jacob Insua‐Rodríguez, Pascal Naef, Hannah Savage…·Devon A. Lawson
This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.