Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer
Jacob Insua‐Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A. Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad S. Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F. Tifrea, , Devon A. Lawson
This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.
bioRxiv · Feb 3, 2026 · PreprintCancer Biology