Author

Ahmed Mohyeldin

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Aaron J. LongworthiD· 2 shared Devon A. LawsoniD· 2 shared Erika ZagniiD· 2 shared Hannah SavageiD· 2 shared Isam Adam· 2 shared Jacob Insua‐RodrígueziD· 2 shared Kai KessenbrockiD· 2 shared Pascal NaefiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Aaron J. LongworthORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis

Timothy P McMullen, Pascal Naef, Erika Zagni, Lei Tian, Eva Zhao, Noah Wechter, Aaron J. Longworth, Isam Adam, Jacob Insua‐Rodríguez, Hannah Savage, Isaac Hur, Sophia A. Garcia, Dennis Ma, Michael H Liew, Sharmila Mallya, , Devon A. Lawson

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

bioRxiv · Oct 10, 2026 · PreprintImmunology

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

Jacob Insua‐Rodríguez, Pascal Naef, Hannah Savage, Isam Adam, Sung Kook Chun, Axel A. Almet, Gautham Prabhakar, Sharon Kwon, Cassandra G Sweet, Sevilla Farah Hennessey, Angela Lincy Prem Antony Samy, Hamad S. Alshetaiwi, Maren Pein, Sharmila Mallya, Delia F. Tifrea, , Devon A. Lawson

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

bioRxiv · Feb 3, 2026 · PreprintCancer Biology

The nascent transcriptome delineates the regulatory landscape in human health and disease

Sagar R Shah, You Chen, Alden King-Yung Leung, Priscila V. Castilho Navarro, Mauricio I. Paramo, Juhi Gupta, Aishwarya Gurumurthy, Rebuma Firdessa-Fite, Annika K K Weimer, Kelly Cochran, Austin Wang, Qian Du, Ahmed Mohyeldin, Dieter M. Egli, Anshul Bharat Kundaje, , Haiyuan Yu

The paper presents a high-resolution atlas of transcriptional regulatory elements in human tissues and disease states using PRO-cap and deep learning models to prioritize noncoding variants.

bioRxiv · Sep 24, 2025 · PreprintGenomics

YAP controls cell migration and invasion through a Rho-GTPase switch

Sagar R. Shah, Chunxiao Ren, Nathaniel D. Tippens, JinSeok Park, Ahmed Mohyeldin, Shuyan Wang, Guillermo Vela, Juan Carlos Martínez-Gutiérrez, Seth S. Margolis, Susanne Schmidt, Alfredo Quiñones‐Hinojosa, Andre Levchenko

This study identifies YAP's role in controlling cell migration and invasion via a Rho-GTPase switch, with implications for glioblastoma progression.

Science Signaling · May 27, 2025Peer-reviewedCancer Biology