Jacob Insua‐Rodríguez

Restoration of deficient IL-15 signaling enhances innate lymphoid cell immunity in brain metastasis

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.