Author

Angela Lincy Prem Antony Samy

University of California, IrvineORCID 0000-0001-6834-5978Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Aaron J. LongworthiD· 3 shared Devon A. LawsoniD· 3 shared Isam Adam· 3 shared Kai KessenbrockiD· 3 shared Sharmila MallyaiD· 3 shared Dennis MaiD· 2 shared Hamad S. AlshetaiwiiD· 2 shared Hannah SavageiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Aaron J. LongworthORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 30, 2026

Cell-of-origin shapes tumor subtype in BRCA1-associated triple-negative breast cancer

Tatyana Lev, Angela Lincy Prem Antony Samy, Sharmila Mallya…·Devon A. Lawson

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

DOI 10.64898/2026.09.29.755499

mousescRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintFeb 3, 2026

Single-cell profiling of synchronous multi-organ metastasis reveals a systemic CD74+ lipid-associated macrophage niche driving polymetastatic breast cancer

Jacob Insua‐Rodríguez, Pascal Naef, Hannah Savage…·Devon A. Lawson

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

2 citations

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintAug 19, 2025

PHLDA2 promotes breast cancer metastasis by co-opting a developmental program for placental vascular remodeling

Paige V. Halas, Hannah Savage, Stephanie J. Hachey…·Devon A. Lawson

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

DOI 10.1101/2025.08.19.670946

humanbulk RNA-seq

𝕏 PostBluesky