Pathological variants in HPDL cause collapse of the neuro-glial unit during human cortical maturation
Matteo Baggiani, Michela Giacich, Valentina Naef…·Devid Damiani
This study investigates the effects of HPDL variants on cortical development, finding synaptic impairment, glial loss, and reactivation of developmental programs in HPDL-deficient cultures.