Valentina Cappello

The extremely low mechanical force generated by nano-pulling induces global changes in the microtubule network, nuclear morphology, and chromatin transcription in neurons

HPDL is critical in human cortical development via regulation of mitochondrial functional properties

This study shows HPDL is essential for cortical development by regulating mitochondrial function and neurogenesis, with implications for SPG83 pathology and potential antioxidant therapies.

A Transfection-Free Approach of Gene Editing via a gold-based nanoformulation of the Cas9 protein

This paper presents a transfection-free method for delivering Cas9:gRNA ribonucleoprotein using gold nanoparticles, achieving effective gene editing in human melanoma cells.

Low forces push the maturation of neural precursors into neurons

The paper shows that mechanical stimulation via magnetic nano-pulling accelerates neural precursor maturation into neurons and alters neuronal network organization.

Axonal plasticity in response to active forces generated through magnetic nano-pulling

This study shows that magnetic nano-pulling induces axonal cytoskeleton remodeling, enhancing outgrowth and synapse maturation through microtubule density increase and local translation promotion.