Martin Middleditch

This study identifies redox-controlled dimerisation as a regulatory mechanism for ethylene biosynthesis enzyme ACO, revealing its role as a redox sensor in plant cells.

This study shows that respiratory heart rate variability pacing improves cardiac output in failing sheep hearts by restoring mitochondrial function and cytoskeletal structure.

The paper revises the biosynthetic pathway for the cofactor F420 in bacteria by identifying the correct substrate for guanylyltransferases and elucidating the role of the C-terminal domain of FbiB.

The paper introduces a Bayesian multivariate multilevel model to analyze hierarchical clinical proteomics data with non-random missingness, showing improved performance over existing methods.