James Antoney

This paper describes a F420-dependent chemogenetic tool that induces and releases protein dimerization by exploiting a mycobacterial oxidoreductase.

The paper develops a cyanamide-inducible system for genome engineering in yeast, enabling selectable marker recycling and promoter characterization.

The paper investigates how active site mutations in FDOR enzymes affect stereoselectivity and reveals that a Tyr-Met mutation reverses stereoselectivity and alters hydrogenation mode.

The paper revises the biosynthetic pathway for the cofactor F420 in bacteria by identifying the correct substrate for guanylyltransferases and elucidating the role of the C-terminal domain of FbiB.