Ivanhoe K. H. Leung

The paper identifies a regulatory mechanism in Mycobacterium tuberculosis that controls metabolic flux through coordinated enzyme abundance and metabolite effects, likened to a mixer tap.

The paper uses time-resolved cryo-EM to show how acetyl-CoA binding induces conformational changes in ICL2, leading to asymmetric catalytic activity.

This paper identifies how acetyl-CoA binding induces allostery in Mycobacterium tuberculosis ICL2, revealing a novel mechanism for enzyme activation and potential therapeutic targets.

This study identifies redox-controlled dimerisation as a regulatory mechanism for ethylene biosynthesis enzyme ACO, revealing its role as a redox sensor in plant cells.

The paper shows redox cycling enhances organic micropollutant removal by restructuring microbial metabolism and degradation pathways through co-metabolic and ROS-driven mechanisms.

The paper investigates the ester bond crosslinking mechanism in bacterial adhesin proteins, confirming a protease-like mechanism through structural, functional, and computational analyses.

The paper identifies microbial enzymes, pathways, and hosts involved in co-metabolic degradation of 24 organic micropollutants in wastewater using multi-omics and functional group analysis.

This study shows Pseudomonas putida KT2440 can degrade several CECs in lab-scale reactors, with enzyme expression profiles linked to degradation via proteomics and LC-MS/MS.