Andrew R. McKinstry-Wu

This study creates a conditional Adra2a knockout mouse line and shows cell-specific contributions of the 2A adrenergic receptor to sedation, hypnosis, and hypothermia.

This study examines changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced unconsciousness and recovery, finding widespread connectivity decreases and cerebellum-specific increases in structure-function coupling.

This study investigates recovery of consciousness and cognition after general anesthesia in humans, finding that executive function recovers before other cognitive domains and frontal cortical activity recovers faster than posterior.