Molecular BiologybioRxivPreprint
Modeling MEK inhibitor-Associated Retinopathy in vitro using human induced pluripotent stem cell-derived retinal pigment epithelial cells
Lola P. Lozano, Madeleine K. Jennisch, Renato Jensen…·Budd A. Tucker
This study investigates the effects of MEK inhibitor selumetinib on hiPSC-derived RPE cells, finding increased internalization of rod outer segments and decreased aquaporin 1 expression, suggesting a mechanism for MEKAR.
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