Luke A. Wiley

This study uses single-cell RNA sequencing to analyze MAC-bound cells in human choroid, revealing patterns of complement deposition and regulator expression in AMD.

This study analyzes metabolites in human retinal pigment epithelium and choroid tissue across aging and macular degeneration stages, identifying key metabolic changes associated with aging.

This study develops a xeno-free 3D retinal differentiation protocol for iPSCs to generate transplantable photoreceptor cells in a cGMP-compliant manner.

This study investigates the effects of MEK inhibitor selumetinib on hiPSC-derived RPE cells, finding increased internalization of rod outer segments and decreased aquaporin 1 expression, suggesting a mechanism for MEKAR.

This study examines sialoglycoconjugates in human choroid and macular degeneration lesions using lectins to identify sialic acid types and their distribution.