Author

Elaine M. Binkley

University of IowaORCID 0000-0003-0464-3372Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Assay:scRNA-seq· 1 Organism:zebrafish· 1

Frequent Co-Authors

Robert F. MullinsiD· 3 shared Brynnon E. HarmaniD· 2 shared Budd A. TuckeriD· 2 shared H. Culver BoldtiD· 2 shared Lola P. LozanoiD· 2 shared Timothy M. BoyceiD· 2 shared Adam J. DupuyiD· 1 shared Alexander BirbrairiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Robert F. MullinsORCID

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3 papers

Recent·Most cited

Cancer BiologyCancer ResearchPeer-reviewedMay 26, 2026

Mitfa-Independent Melanocyte Progenitors are Highly Susceptible to GNAQ-induced Uveal Melanoma in Adult Zebrafish

Julius I. Yevdash, Delaney Robinson, Rachel Moore…·Colin Kenny

This study shows that Mitfa-independent melanocyte progenitors in zebrafish are more susceptible to GNAQ-induced uveal melanoma than differentiated melanocytes.

1 citationtop 4%

zebrafishscRNA-seq

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Pharmacology & ToxicologybioRxivPreprintApr 14, 2026

Using Patient iPSC-derived Retinal Pigment Epithelial Cells to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy

Lola P. Lozano, Timothy M. Boyce, Andrew P. Groves…·Budd A. Tucker

The paper compares MEK inhibitor effects on iPSC-derived RPE cells from patients with and without MEKAR, finding differential gene expression and phagocytic activity.

1 citation

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintOct 3, 2025

Modeling MEK inhibitor-Associated Retinopathy in vitro using human induced pluripotent stem cell-derived retinal pigment epithelial cells

Lola P. Lozano, Madeleine K. Jennisch, Renato Jensen…·Budd A. Tucker

This study investigates the effects of MEK inhibitor selumetinib on hiPSC-derived RPE cells, finding increased internalization of rod outer segments and decreased aquaporin 1 expression, suggesting a mechanism for MEKAR.

2 citations

humanexperimental assay

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