Mary E. Comeau

This paper identifies 41 risk loci for juvenile idiopathic arthritis, including 14 novel ones, and presents a polygenic risk score associated with age of onset, along with functional mechanisms involving DNA topology and an HLA-A*02:01-ERAP2 interaction.

The paper performs deep resequencing of the 1q22 locus in non-lobar ICH cases and controls to identify causal variants and mechanisms.

This paper develops a genomic risk score for intracerebral hemorrhage using genome-wide association data and validates its predictive power in multiple cohorts.

The paper identifies 554 consensus genes in outbred rats and humans associated with body weight and BMI, revealing shared genetic regulatory mechanisms relevant for obesity.

The paper identifies subtype-specific genetic loci associated with stroke subtypes and finds heterogeneity in their effects across different stroke types.