Anthony L. Shiver

Eubiota enables autonomous discovery in the gut microbiome by integrating modular agents and reinforcement learning, identifying key pathways and designing therapeutic interventions.

The paper updates GapMind to include novel enzymes for amino acid biosynthesis, reducing pathway gaps in prokaryotes from 1.4 to 0.7 per genome.

This paper develops a fast, cheap protocol for assembling ordered transposon insertion libraries in anaerobic bacteria, using cell sorting and barcoded transposons to improve accuracy and efficiency.

The paper uses chemical-genetic analysis of RNA polymerase mutants to uncover structure-function relationships and physiological trade-offs in Escherichia coli.