Jason M. Peters

The paper identifies surface receptor masking and internal defenses as barriers to phage therapy in Pseudomonas aeruginosa clinical isolates and presents strategies to overcome these barriers through phage engineering.

The paper identifies genomic targets for improving anaerobic chemical tolerance in Zymomonas mobilis using orthogonal gene perturbation screens and validates findings through gene deletions.

This paper identifies SigAb as a metal stress-responsive ECF σ factor in Acinetobacter baumannii, showing it directly regulates a small set of genes and indirectly controls hundreds involved in metal resistance and fitness.

This study uses CRISPR interference to screen chemical inhibitors against essential genes in A. baumannii, revealing gene-inhibitor interactions and potential drug targets.

This study identifies how altering translation in E. coli mitigates the growth inhibition caused by chemically stabilized G-quadruplexes.

This study identifies Pseudomonas aeruginosa genes whose partial knockdown increases vulnerability in a murine pneumonia model, highlighting potential targets for antibacterial strategies.

This study shows minocycline enhances macrophage killing of Acinetobacter baumannii and reduces inflammation in a dose-dependent manner, suggesting improved in vivo efficacy.

The paper develops inducible gene expression systems for Escherichia coli and Acinetobacter baumannii, enabling cross-species functional studies of gene regulation.

The paper uses double-CRISPRi to systematically analyze genetic interactions in Bacillus subtilis, identifying over 1000 interactions and revealing roles of paralogous genes in cell division.

The paper introduces Mobile-CRISPRi, a system for gene knockdown in Vibrio species, showing it effectively modulates gene expression and phenotypes.

The paper introduces PHAGEPACK, a CRISPR-based assay to systematically identify host genes affecting phage infectivity, revealing new pathways in both permissive and non-permissive E. coli.

The paper develops CRISPRtOE, a genome-scale overexpression platform for Proteobacteria, demonstrating its use in Escherichia coli and Zymomonas mobilis to identify antibiotic and engineering targets.

This study identifies genetic vulnerabilities and antibiotic sensitivities in Acinetobacter baumannii using CRISPRi, revealing key targets and interactions for therapeutic development.

This study identifies conditionally essential genes in Zymomonas mobilis for aerobic and anaerobic growth using CRISPRi-seq, revealing roles of DNA repair and respiratory complexes in energy coupling and isoprenoid biosynthesis.

The paper uses chemical-genetic analysis of RNA polymerase mutants to uncover structure-function relationships and physiological trade-offs in Escherichia coli.

The paper develops a CRISPRi system to modulate gene expression in bacteria and shows that essential gene expression-fitness relationships are conserved across species.