Author

Hendrik Osadnik

University of California, San FranciscoORCID 0000-0002-1624-1322Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Systems Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:E. coli· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Carol A. GrossiD· 3 shared Horia TodoriD· 2 shared Jason M. PetersiD· 2 shared Anthony L. ShiveriD· 1 shared Byoung‐Mo KooiD· 1 shared Cameron C. Hearne· 1 shared Elizabeth A. CampbelliD· 1 shared Hannes BrabergiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersSystems Biology

Carol A. GrossORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Systems BiologyMolecular CellPeer-reviewedMay 1, 2021

Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs

Anthony L. Shiver, Hendrik Osadnik, Jason M. Peters…·Carol A. Gross

The paper uses chemical-genetic analysis of RNA polymerase mutants to uncover structure-function relationships and physiological trade-offs in Escherichia coli.

22 citations

E. coliexperimental assay

𝕏 PostBluesky

Systems BiologyProceedings of the National Academy of SciencesPeer-reviewedDec 14, 2020

Rewiring the specificity of extra-cytoplasmic function sigma factors

Horia Todor, Hendrik Osadnik, Elizabeth A. Campbell…·Carol A. Gross

The paper deciphers the DNA-specificity code of ECF σ factors to predict their regulons and reveals their varied regulatory roles in bacterial gene regulation.

27 citations

statistical modelgene regulatory network inference

𝕏 PostBluesky

Systems BiologyCell SystemsPeer-reviewedOct 19, 2020

Modulated efficacy CRISPRi reveals evolutionary conservation of essential gene expression-fitness relationships in bacteria

John S. Hawkins, Melanie R. Silvis, Byoung‐Mo Koo…·Carol A. Gross

The paper develops a CRISPRi system to modulate gene expression in bacteria and shows that essential gene expression-fitness relationships are conserved across species.

130 citationstop 3%

E. colimouse

𝕏 PostBluesky