Chris Kay

Transcriptome and evolutionary analysis of Pseudotrichomonas keilini, a free-living anaerobic eukaryote

This study sequenced the transcriptome of Pseudotrichomonas keilini, a free-living parabasalid, and compared its genome to parasitic relatives to understand evolutionary adaptations to anaerobic lifestyles.

Single-cell transcriptomics reveals expression profiles of Trypanosoma brucei sexual stages

The paper uses single-cell RNA sequencing to identify and characterize sexual stages in Trypanosoma brucei, revealing gene expression patterns associated with gamete formation.

Length of uninterrupted CAG repeats, independent of polyglutamine size, results in increased somatic instability and hastened age of onset in Huntington disease

This study identifies a genetic variant that reduces interruption between CAG and CCG repeats in the HTT gene, leading to earlier onset of Huntington disease and increased somatic instability.

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease

The paper identifies a human SNP that modifies post-translational myristoylation of huntingtin, altering its proteolysis and contributing to Huntington disease pathogenesis.