Alison D. Tang

The paper develops FLAIR2 to detect haplotype-specific transcript variation using long-read sequencing, revealing ADAR's role in splicing and RNA editing in lung cancer.

Benchmarking six long-read RNA-seq protocol-platform combinations and 14 tools across human, mouse, and manatee shows read length and accuracy drive isoform detection, depth drives quantification.

FLAIR3 integrates SNV, fusion, and isoform analysis using long-read RNA-seq to better understand cancer drivers by capturing full-length molecules and their variant interactions.

The paper uses nanopore sequencing to analyze full-length transcripts in CLL samples with and without SF3B1 mutations, revealing altered intron retention and splicing patterns.

The paper uses long-read sequencing to identify U2AF1 S34F mutation-induced isoform changes in lung cancer, revealing novel transcripts and functional consequences.

The paper uses nanopore sequencing to analyze poly(A) RNA from human cells, identifying long transcripts and modifications not captured by traditional methods.