Colette Felton

The paper uses long-read sequencing to study how nucleosome positioning affects isoform expression by analyzing chromatin and RNA in yeast.

The paper introduces SMAdd-seq, a method to profile chromatin accessibility using small molecule intercalation and nanopore sequencing, and demonstrates its application in yeast.

This study shows U2AF1S34F enhances lung cell tumorigenicity when combined with KRAS mutations and environmental stress, altering splicing and stress responses.

The paper develops FLAIR2 to detect haplotype-specific transcript variation using long-read sequencing, revealing ADAR's role in splicing and RNA editing in lung cancer.

Benchmarking six long-read RNA-seq protocol-platform combinations and 14 tools across human, mouse, and manatee shows read length and accuracy drive isoform detection, depth drives quantification.

FLAIR3 integrates SNV, fusion, and isoform analysis using long-read RNA-seq to better understand cancer drivers by capturing full-length molecules and their variant interactions.

This study uses RNA-seq data to detect somatic variants and identify cancer drivers in 1,359 samples, showing RNA-seq can effectively replace WES/WGS for this task.