Author

Melina Ioannidis

University of GroningenORCID 0000-0001-7142-428XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Danny IncarnatoiD· 2 shared Geert van den BogaartiD· 2 shared Martijn den Ouden· 2 shared Pieter Grijpstra· 2 shared Sjors MaasseniD· 2 shared Frans BianchiiD· 1 shared Hjalmar R. BoumaiD· 1 shared Joke Wortel· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Danny IncarnatoORCID

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2 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 24, 2025

4-HNE reduces phagocytosis through the expression of Synaptotagmin 1 in human monocyte-derived macrophages

Melina Ioannidis, Martijn den Ouden, Sietse J. Dijt…·Geert van den Bogaart

The paper shows that 4-HNE increases SYT1 expression in macrophages, which inhibits phagocytosis of bacteria.

DOI 10.1101/2025.11.24.690103

humanbulk RNA-seq

ImmunologybioRxivPreprintNov 24, 2025

4-Hydroxynonenal suppresses IL-10 production during infection

Melina Ioannidis, Sjors Maassen, Lisanne Boekhoud…·Geert van den Bogaart

This study shows that 4-HNE suppresses IL-10 production in sepsis while leaving IL-6 and TNF- unaffected, through mechanisms involving HIF-1 and NF-κB signaling.

1 citation

humanproteomics