Author

Pieter Grijpstra

University of Groningen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Danny IncarnatoiD· 2 shared Geert van den BogaartiD· 2 shared Martijn den Ouden· 2 shared Melina IoannidisiD· 2 shared Sjors MaasseniD· 2 shared Frans BianchiiD· 1 shared Hjalmar R. BoumaiD· 1 shared Joke Wortel· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Danny IncarnatoORCID

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2 papers

Recent·Most cited

4-HNE reduces phagocytosis through the expression of Synaptotagmin 1 in human monocyte-derived macrophages

Melina Ioannidis, Martijn den Ouden, Sietse J. Dijt, Danny Incarnato, Pieter Grijpstra, Joke Wortel, Matthijs Verhage, Sjors Maassen, Geert van den Bogaart

The paper shows that 4-HNE increases SYT1 expression in macrophages, which inhibits phagocytosis of bacteria.

bioRxiv · Nov 24, 2025 · PreprintMolecular Biology

4-Hydroxynonenal suppresses IL-10 production during infection

Melina Ioannidis, Sjors Maassen, Lisanne Boekhoud, Martijn den Ouden, Mihai Simioniuc, Pieter Grijpstra, Danny Incarnato, Frans Bianchi, Hjalmar R. Bouma, Geert van den Bogaart

This study shows that 4-HNE suppresses IL-10 production in sepsis while leaving IL-6 and TNF- unaffected, through mechanisms involving HIF-1 and NF-κB signaling.

bioRxiv · Nov 24, 2025 · PreprintImmunology