Author

Carole L. Linster

University of LuxembourgORCID 0000-0001-7143-0719Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:metabolomics· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Christian JägeriD· 2 shared Floriane GavottoiD· 2 shared Ursula Heins-MarroquiniD· 2 shared Alexander D. Crawford· 1 shared Anaïs CarpentieriD· 1 shared Carla MerinoiD· 1 shared Corey M. GriffithiD· 1 shared Emma SchymanskiiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Christian JägerORCID

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2 papers

Recent·Most cited

BiochemistryNature Chemical BiologyPeer-reviewedMar 19, 2025

CLYBL averts methylmalonyl-CoA mutase inhibition and loss of vitamin B12 by repairing malyl-CoA

Corey M. Griffith, Jean‐François Conrotte, Parisa Paydar…·Carole L. Linster

The paper identifies CLYBL as a metabolite repair enzyme for malyl-CoA, showing it alleviates B12 deficiency by preventing MCM inhibition.

10 citationstop 4%

humanmetabolomics

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Molecular BiologyLife Science AlliancePeer-reviewedJan 9, 2024

CLN3 deficiency leads to neurological and metabolic perturbations during early development

Ursula Heins-Marroquin, Randolph R. Singh, Simon Perathoner…·Carole L. Linster

This study shows that CLN3 deficiency in zebrafish leads to metabolic changes, including GPD accumulation and BMP reduction, and confirms these findings in human stem cell models.

20 citationstop 3%

zebrafishmetabolomics

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