Author
University of BristolORCID 0000-0001-7144-9700Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Alexandros Rammos, Sarah Jane Lewis, Amy Davies…·Evie Stergiakouli
The paper investigates whether common genetic variants contribute to neurodevelopmental risks in children with cleft lip/palate, finding no strong genetic correlation with psychiatric traits but noting independent clinical relevance of polygenic risk scores.
Kyle Dack, Kerstin U. Ludwig, Evie Stergiakouli…·Sarah Jane Lewis
This study conducts GWAS on orofacial cleft subtypes, identifying 27 genome-wide significant regions, including novel loci, and highlights genetic heterogeneity and homogeneity across subtypes.
Christina Dardani, Laurence J Howe, Nandita Mukhopadhyay…·Gemma C. Sharp
This study investigates whether genetic liability to non-syndromic cleft lip/palate influences educational attainment and intelligence, finding little evidence of shared genetic causation.
Laurence J Howe, Tom G. Richardson, Ryan Arathimos…·Gemma C. Sharp
The paper identifies three loci where genetic liability to non-syndromic cleft lip/palate may be mediated by DNA methylation variation in blood and tissue.
Laurence J Howe, Myoung Keun Lee, Gemma C. Sharp…·Sarah Jane Lewis
The paper investigates genetic overlap between non-syndromic cleft lip/palate and facial morphology using polygenic risk scores and Mendelian randomization, finding a causal relationship with philtrum width.